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KMID : 1161420200230080834
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Journal of Medicinal Food
2020 Volume.23 No. 8 p.834 ~ p.840
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Curcumin-Based Treatment for Macular Edema from Uncommon Etiologies: Efficacy and Safety Assessment
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Ferrara Mariantonia
Allegrini Davide
Sorrentino Tania
Sborgia Giancarlo
Parmeggiani Francesco
Borgia Alfredo
Romano Mario R.
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Abstract
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The aim of this study was to investigate the efficacy and safety of curcumin formulation with a polyvinylpyrrolidone-hydrophilic carrier (CHC*; Diabec®?AlfaIntes, Italy) for the treatment of macular edema (ME) from uncommon etiologies. We conducted retrospective interventional case series, reviewing the medical records of patients referred to the Eye Center, Humanitas Hospital, Bergamo due to persistent ME related to uncommon causes and treated by oral administration of CHC. The main outcomes assessed were best-corrected visual acuity (BCVA), central macular thickness (CMT), and the presence of intraretinal and/or subretinal fluid (SRF). Only patients with a minimum follow-up (f/u) of 6 months were included. The occurrence of any adverse effect was registered. Thirty-one eyes of 30 patients were included, with a mean f/u of 8.32?±?1.77 months. Of them, 9 patients (10 eyes) were affected by postoperative ME and 21 by chronic central serous chorioretinopathy. Median BCVA significantly improved after treatment, changing from 0.3 [0.16?0.5] to 0.1 [0?0.3] logarithm of the minimum angle of resolution (P?
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KEYWORD
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central serous chorioretinopathy, curcumin, macular edema, postoperative macular edema
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